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<h1 id="firstHeading" class="firstHeading mw-first-heading">Catechol-<i>O</i>-Methyltransferase</h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_Catechol-O-Methyltransferase" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Catechol-<i>O</i>-Methyltransferase
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<td colspan="3"><span typeof="mw:File"></span>
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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">Bändermodell von menschlicher S-COMT im Komplex mit 3,5-Dinitrocatechol (blau) and S-Adenosylmethionin (gelb)
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<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3BWM">3BWM</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3BWY">3BWY</a></span>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">271 Aminosäuren, 30.037 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Da</a>
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<td><a href="Koenzym" class="mw-redirect" title="Koenzym">Kofaktor</a>
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<td colspan="2" style="text-align:center;"><a href="SAM" class="mw-redirect mw-disambig" title="SAM">SAM</a>
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<td><a href="Isoform" title="Isoform">Isoformen</a>
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<td colspan="2" style="text-align:center;">löslich, membrangebunden
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=2228">COMT</a></i>
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<td>Externe IDs
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<td colspan="2" class="">
<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/116790">116790</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P21964">P21964</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation
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<td><a href="EC-Nummer" title="EC-Nummer">EC, Kategorie</a>
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<td colspan="2" class="" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.6">2.1.1.6</a>, <a href="Methyltransferase" class="mw-redirect" title="Methyltransferase">Methyltransferase</a>
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<td>Reaktionsart
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<td colspan="2" style="text-align:center;">Übertragung einer Methylgruppe
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<td>Substrat
</td>
<td colspan="2" style="text-align:center;">S-Adenosylmethionin + Catecholamin
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<td>Produkte
</td>
<td colspan="2" style="text-align:center;">S-Adenosyl-L-Homocystein + <a href="Guajacol" title="Guajacol">Guajacol</a>-Derivat
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<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P21964">COMT</a>
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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>
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<td colspan="2" style="text-align:center;">Lebewesen
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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a> (Mensch)
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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
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<td colspan="2"><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1312&rn=1">1312</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
</td>
<td colspan="2"><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000093010;db=core">ENSG00000093010</a></small></small></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
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<td colspan="2"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P21964">P21964</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000754.3">NM_000754.3</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000745.1">NP_000745.1</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
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<td colspan="2"><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1312">1312</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p>Die <b>Catechol-<i>O</i>-Methyltransferase</b> (Gen: <i>COMT</i>) ist ein <a href="Enzym" title="Enzym">Enzym</a>, das verschiedene <a href="Katecholamine" title="Katecholamine">Catecholamine</a>, darunter natürliche <a href="Botenstoff" title="Botenstoff">Botenstoffe</a> und neuroaktive Arzneistoffe, O-methyliert und damit inaktiviert und dem <a href="Katabolismus" title="Katabolismus">Abbau</a> zuführt. Es ist Teil des Katecholamin-Abbaus und des <a href="Fremdstoffmetabolismus" class="mw-redirect" title="Fremdstoffmetabolismus">Fremdstoffmetabolismus</a>. COMT ist in allen Lebewesen zu finden und wird insbesondere im <a href="Gehirn" title="Gehirn">Gehirn</a>, in der <a href="Leber" title="Leber">Leber</a> und <a href="Plazenta" title="Plazenta">Plazenta</a>, sowie in <a href="Lymphozyt" title="Lymphozyt">Lymphozyten</a> und <a href="Erythrozyt" title="Erythrozyt">Erythrozyten</a> <a href="Genexpression" title="Genexpression">exprimiert</a>. Beim Menschen gibt es zwei <a href="Isoform" title="Isoform">Isoformen</a> der COMT: MB-COMT ist membrangebunden und S-COMT (der die ersten 50 Aminosäuren fehlen) frei beweglich.
</p><p>COMT wurde vom US-amerikanischen <a href="Biochemiker" class="mw-redirect" title="Biochemiker">Biochemiker</a> <a href="Julius_Axelrod" title="Julius Axelrod">Julius Axelrod</a> entdeckt.
</p>
<div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2></div>
<p>COMT deaktiviert insbesondere in den <a href="Sympathikus" title="Sympathikus">sympathischen</a> Nervenenden das <a href="Noradrenalin" title="Noradrenalin">Noradrenalin</a>, das <a href="Adrenalin" title="Adrenalin">Adrenalin</a> und das <a href="Dopamin" title="Dopamin">Dopamin</a>. Die Inaktivierung dieser <a href="Neurotransmitter" title="Neurotransmitter">Neurotransmitter</a> erfolgt durch Übertragung einer <a href="Methylgruppe" title="Methylgruppe">Methylgruppe</a> vom <a href="S-Adenosylmethionin" title="S-Adenosylmethionin"><i>S</i>-Adenosylmethionin</a> (SAM) auf eine phenolische Hydroxygruppe durch die Catechol-<i>O</i>-Methyltransferase, an die sich die oxidative <a href="Desaminierung" title="Desaminierung">Desaminierung</a> durch die <a href="Monoaminooxidase" class="mw-redirect" title="Monoaminooxidase">Monoaminooxidase</a> (MAO) anschließt.
</p><p>Die COMT metabolisiert – ebenfalls durch Methylierung – auch verschiedene <a href="Arzneistoff" title="Arzneistoff">Arzneistoffe</a>, so wie die in der Therapie des <a href="Morbus_Parkinson" class="mw-redirect" title="Morbus Parkinson">Morbus Parkinson</a> verwendeten Verbindungen <a href="Levodopa" title="Levodopa">Levodopa</a> und <a href="Dopamin" title="Dopamin">Dopamin</a>. Um diese Deaktivierung auszuschalten, wurden <a href="COMT-Hemmer" title="COMT-Hemmer">COMT-Hemmer</a> entwickelt.
</p>
<div class="mw-heading mw-heading2"><h2 id="Pathologie">Pathologie</h2></div>
<p>COMT-<a href="Polymorphismus" title="Polymorphismus">Polymorphismen</a>, also das Auftreten von Genvarianten, werden mit einer Reihe von psychischen Veränderungen wie <a href="Angstst%C3%B6rung" title="Angststörung">Angststörungen</a> und <a href="Schizophrenie" title="Schizophrenie">Schizophrenie</a>, aber auch speziell Essstörungen und Übergewicht in Verbindung gebracht. Diese Zusammenhänge, sowie auch die Rolle der COMT in der Verarbeitung von Schmerzen, werden derzeit erforscht. Die Ergebnisse zur Schizophrenie sind widersprüchlich.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p><p>Umweltgifte, aber auch die <a href="Soja" class="mw-redirect" title="Soja">Soja</a>-Inhaltsstoffe <a href="Daidzein" title="Daidzein">Daidzein</a> und <a href="Genistein" title="Genistein">Genistein</a>, können die COMT blockieren und so zu einer Ansammlung von Abbauprodukten mit folgenden Schäden am Organismus beitragen.
</p><p>In einer retrospektiven Studie konnte gezeigt werden, dass Patienten mit einer erniedrigten COMT-Aktivität häufiger einen <a href="Schock_(Medizin)" title="Schock (Medizin)">Schock</a> bei <a href="Bypass_(Medizin)" title="Bypass (Medizin)">Bypassoperationen</a> erleiden und ein höheres Sterblichkeitsrisiko während der Operation haben.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p><a href="Pr%C3%A4eklampsie" title="Präeklampsie">Präeklampsie</a> ist mit COMT-Mangel assoziiert.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Ross JR, Riley J, Taegetmeyer AB, <i>et al.</i>: <cite style="font-style:italic">Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects</cite>. In: <cite style="font-style:italic"><a href="Cancer_(Zeitschrift)" title="Cancer (Zeitschrift)">Cancer</a></cite>. 112. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, März 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1390–403</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/cncr.23292">10.1002/cncr.23292</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18257092?dopt=Abstract">PMID 18257092</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Genetic+variation+and+response+to+morphine+in+cancer+patients%3A+catechol-O-methyltransferase+and+multidrug+resistance-1+gene+polymorphisms+are+associated+with+central+side+effects&rft.au=Ross+JR%2C+Riley+J%2C+Taegetmeyer+AB%2C+...&rft.date=2008-03&rft.doi=10.1002%2Fcncr.23292&rft.genre=journal&rft.issue=6&rft.jtitle=Cancer&rft.pages=1390-403&rft.pmid=18257092&rft.volume=112.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Bassett AS, Chow EW: <cite style="font-style:italic">Schizophrenia and 22q11.2 deletion syndrome</cite>. In: <cite style="font-style:italic">Curr Psychiatry Rep</cite>. 10. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, April 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>148–57</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18474208?dopt=Abstract">PMID 18474208</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Schizophrenia+and+22q11.2+deletion+syndrome&rft.au=Bassett+AS%2C+Chow+EW&rft.date=2008-04&rft.genre=journal&rft.issue=2&rft.jtitle=Curr+Psychiatry+Rep&rft.pages=148-57&rft.pmid=18474208&rft.volume=10.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Silberschmidt AL, Sponheim SR: <cite style="font-style:italic">Personality in relation to genetic liability for schizophrenia and bipolar disorder: differential associations with the COMT Val 108/158 Met polymorphism</cite>. In: <cite style="font-style:italic">Schizophr. Res.</cite> 100. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1–3</span>, März 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>316–24</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.schres.2007.12.467">10.1016/j.schres.2007.12.467</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18201871?dopt=Abstract">PMID 18201871</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Personality+in+relation+to+genetic+liability+for+schizophrenia+and+bipolar+disorder%3A+differential+associations+with+the+COMT+Val+108%2F158+Met+polymorphism&rft.au=Silberschmidt+AL%2C+Sponheim+SR&rft.date=2008-03&rft.doi=10.1016%2Fj.schres.2007.12.467&rft.genre=journal&rft.issue=1-3&rft.jtitle=Schizophr.+Res.&rft.pages=316-24&rft.pmid=18201871&rft.volume=100.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">Sanders AR, Duan J, Levinson DF, <i>et al</i>: <cite style="font-style:italic">No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics</cite>. In: <cite style="font-style:italic">Am J Psychiatry</cite>. 165. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, April 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>497–506</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1176/appi.ajp.2007.07101573">10.1176/appi.ajp.2007.07101573</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18198266?dopt=Abstract">PMID 18198266</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=No+significant+association+of+14+candidate+genes+with+schizophrenia+in+a+large+European+ancestry+sample%3A+implications+for+psychiatric+genetics&rft.au=Sanders+AR%2C+Duan+J%2C+Levinson+DF%2C+...&rft.date=2008-04&rft.doi=10.1176%2Fappi.ajp.2007.07101573&rft.genre=journal&rft.issue=4&rft.jtitle=Am+J+Psychiatry&rft.pages=497-506&rft.pmid=18198266&rft.volume=165.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Haase-Fielitz A, Haase M, Bellomo R et al.: <i>Decreased Catecholamine Degradation Associates with Shock and Kidney Injury after Cardiac Surgery</i>, In: <i><a href="J_Am_Soc_Nephrol" class="mw-redirect" title="J Am Soc Nephrol">J Am Soc Nephrol</a></i>. 2009, 20:1393-1403. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19406978?dopt=Abstract">PMID 19406978</a></span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P21964">P21964</a></span>
</li>
<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Ho PW, Garner CE, Ho JW, <i>et al.</i>: <cite style="font-style:italic">Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk</cite>. In: <cite style="font-style:italic">Curr. Drug Metab.</cite> 9. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, Mai 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>304–9</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18473748?dopt=Abstract">PMID 18473748</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Estrogenic+phenol+and+catechol+metabolites+of+PCBs+modulate+catechol-O-methyltransferase+expression+via+the+estrogen+receptor%3A+potential+contribution+to+cancer+risk&rft.au=Ho+PW%2C+Garner+CE%2C+Ho+JW%2C+...&rft.date=2008-05&rft.genre=journal&rft.issue=4&rft.jtitle=Curr.+Drug+Metab.&rft.pages=304-9&rft.pmid=18473748&rft.volume=9.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Ho PW, Chu AC, Kwok KH, <i>et al.</i>: <cite style="font-style:italic">Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells</cite>. In: <cite style="font-style:italic">Curr. Drug Metab.</cite> 9. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, Mai 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>276–9</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18473745?dopt=Abstract">PMID 18473745</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Effects+of+plasticisers+and+related+compounds+on+the+expression+of+the+soluble+form+of+catechol-O-methyltransferase+in+MCF-7+cells&rft.au=Ho+PW%2C+Chu+AC%2C+Kwok+KH%2C+...&rft.date=2008-05&rft.genre=journal&rft.issue=4&rft.jtitle=Curr.+Drug+Metab.&rft.pages=276-9&rft.pmid=18473745&rft.volume=9.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text">Lehmann L, Jiang L, Wagner J: <cite style="font-style:italic">Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells</cite>. In: <cite style="font-style:italic"><a href="Carcinogenesis" title="Carcinogenesis">Carcinogenesis</a></cite>. 29. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, Februar 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>363–70</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1093/carcin%2Fbgm235">10.1093/carcin/bgm235</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18192686?dopt=Abstract">PMID 18192686</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Soy+isoflavones+decrease+the+catechol-O-methyltransferase-mediated+inactivation+of+4-hydroxyestradiol+in+cultured+MCF-7+cells&rft.au=Lehmann+L%2C+Jiang+L%2C+Wagner+J&rft.date=2008-02&rft.doi=10.1093%2Fcarcin%2Fbgm235&rft.genre=journal&rft.issue=2&rft.jtitle=Carcinogenesis&rft.pages=363-70&rft.pmid=18192686&rft.volume=29.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text">Kanasaki K, Palmsten K, Sugimoto H, <i>et al.</i>: <cite style="font-style:italic">Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia</cite>. In: <cite style="font-style:italic"><a href="Nature" title="Nature">Nature</a></cite>. 453. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>7198</span>, Juni 2008, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1117–21</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/nature06951">10.1038/nature06951</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18469803?dopt=Abstract">PMID 18469803</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Catechol-O-Methyltransferase&rft.atitle=Deficiency+in+catechol-O-methyltransferase+and+2-methoxyoestradiol+is+associated+with+pre-eclampsia&rft.au=Kanasaki+K%2C+Palmsten+K%2C+Sugimoto+H%2C+...&rft.date=2008-06&rft.doi=10.1038%2Fnature06951&rft.genre=journal&rft.issue=7198&rft.jtitle=Nature&rft.pages=1117-21&rft.pmid=18469803&rft.volume=453.+Jahrgang" style="display:none"> </span></span>
</li>
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